iZumi Bio and Kyoto University Form Collaboration to Advance Induced Pluripotent Stem Cell Technology

04/14/09
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Former Vice President Al Gore endorses Trans-Pacific collaboration to promote use of patient cells for drug discovery and, development and cell-based therapies.

Former Vice President Al Gore Endorses Trans-Pacific Collaboration to Promote Use of Patient Cells for Drug Discovery and, Development and Cell-Based Therapies

South San Francisco, CA and Kyoto, Japan - April 14, 2009 – iZumi Bio, Inc., and Kyoto University’s Center for iPS Cell Research and Application (CiRA), today announced a collaboration to promote the basic research, development and application of induced pluripotent stem (iPS) cell technology – a form of cellular reprogramming which originated in Japan – with the goal of advancing drug discovery and enabling cell-based therapies.

“Stem cell research holds great promise for the creation of new therapies that could revolutionize the treatment of disorders such as Parkinson’s disease, diabetes and muscular dystrophy. The discovery that iPS cell technology brings, that “stem cell-like” cells can be generated from a small amount of human skin rather than from embryos, opens a new door for stem cell research and its application to therapeutic discovery,” said Al Gore, former Vice President of the United States and a partner at venture capital firm Kleiner Perkins Caufield and Byers. Noting that Science Magazine named cellular reprogramming the "breakthrough of the year” in 2008, Gore concluded, “The partnership between these two leading organizations is a critical step in furthering this research and turning stem cell research into therapeutic realities sooner.” Through the collaboration, iZumi and CiRA will exchange part of their representative human iPS cell lines derived by various methods. The two organizations also will conduct comparison and characterization studies independently but will share their results to determine which methods produce the most appropriate iPS cell lines for drug screening and development, and those most suitable for cell-based therapy. “This collaboration, which is focused on the advancement of iPS cell technology, will help us attain our goal of making drug discovery and development faster, more efficient and informed in order to create new therapeutics for unmet medical needs. Our approach is based on a paradigm shift that puts the patient at the forefront of the drug discovery process. Using patient and disease-specific cells to develop assays and screening systems has the potential to change the way drug discovery has been conducted to date by shortening the time to clinic through the selection of drug candidates with a higher probability of success,” said John P. Walker, chief executive officer of iZumi. “We will initially focus on three neurological disorders, including Parkinson’s disease, spinal muscular atrophy and amyotrophic lateral sclerosis, because these conditions currently have limited therapeutic treatments, and because scientists have demonstrated the ability to differentiate the affected cell types in these disorders. Through our collaboration with the Gladstone Institute, we also are focusing on cardiovascular disorders, including calcific aortic valve disease.”

iZumi and CiRA respectively offer the capability to take skin cells from a diseased patient with known genotypic and phenotypic information and reprogram the cells to behave similarly to human embryonic stem cells. These iPS cells can then be changed into various cell types in the body using directed differentiation. The differentiated cells are then transformed into cell-based, disease-specific assays to identify small molecules, biologics or other agents for drug discovery.

“We are very pleased to collaborate with iZumi, a major biotechnology venture in the United States, on the basic research to help advance this important technology. I expect that this collaboration will contribute to establishing an evaluation method for selecting safe iPS cell lines and accelerating the development of iPS cell technology globally.” said Dr. Shinya Yamanaka, director of Center for iPS Research and Application (CiRA) at Kyoto University. ”To realize clinical applications of iPS cell technology as soon as possible, CiRA will form partnerships with research institutions both in and outside of Japan to promote global collaboration.”

In 2006, Dr. Yamanaka announced that his lab succeeded in inducing iPS cells in mouse by using four transgenes – Oct3/4, Sox2, Klf4 and c-Myc – delivered into fibroblasts via retroviral vectors, which became the world’s first report of its kind. He also reported the generation of human iPS cells the following year. iPS cell technology has the potential to avoid ethical issues and the risks of immune rejection – major obstacles for embryonic stem cell use in the clinic. Dr. Yamanaka’s seminal papers have led to an explosion of renewed interest and focus in stem cell research worldwide. Recognized as a pioneer in the field of iPS cell technology, he now conducts research activities mainly at CiRA.
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